DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia Running title: DNA methylation patterns in childhood ALL

1) Molecular Medicine, Department of Medical Sciences, Uppsala University, Sweden. 2) Department of Pediatrics, University and University Hospital, Tromsoe, Norway. 3) Department of Clinical Sciences, Pediatrics, University of Umeå, Sweden. 4) Childhood Cancer Research Unit, Dept of Women and Child Health, Astrid Lindgren Children ́s Hospital, Karolinska University Hospital, Stockholm, Sweden. 5) Department of Pediatrics, Landspitalinn, Reykjavik, Iceland. 6) Division of Hematology/Oncology and Stem Cell Transplantation, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. 7) Pediatric Clinic II, Rigshospitalet, and the Medical Faculty, the Institute of Gynecology, Obstetrics and Pediatrics, the University of Copenhagen, Copenhagen, Denmark. 8) Cancer Pharmacology and Informatics, Department of Medical Sciences, Uppsala University, Sweden.9) Department of Women's and Children's Health, University Children's Hospital, Uppsala, Sweden.